A recent article from SupplySide Supplement Journal highlights the growing interest in paraxanthine, the primary metabolite of caffeine, for its unique ability to support alertness, focus, and cognitive function—while potentially reducing the common side effects often associated with caffeine consumption.
What is Paraxanthine?
Paraxanthine is one of three major metabolites produced when the body breaks down caffeine. It accounts for roughly 70–80% of caffeine’s metabolism in humans. Unlike the other two metabolites—theobromine and theophylline—paraxanthine is believed to be responsible for many of caffeine’s most desirable effects.
“Paraxanthine delivers the same stimulating benefits people associate with caffeine—like improved alertness and mental clarity—but without the side effects tied to compounds like theobromine and theophylline, which can sometimes cause overstimulation or digestive discomfort,” says Shawn Baier, Vice President of Business Development at TSI Group.
Cognitive and Performance Benefits
A recent study highlights paraxanthine’s potential to support:
- Improved alertness and mental clarity¹
- Better focus and faster reaction times¹
- Cognitive functions such as memory and reasoning¹
The article notes that a single 200 mg dose of enfinity® (paraxanthine) has been shown in clinical studies to improve markers of attention and mental performance¹.
Additionally, early findings suggest paraxanthine may have applications beyond energy and focus—including possible roles in healthy aging and sports nutrition—making it a versatile ingredient for a wide range of functional products.
A Caffeine Alternative on the Rise
As more consumers seek alternatives to caffeine that deliver mental and physical energy without the jitteriness or crash, paraxanthine is gaining traction. Its targeted effects and cleaner experience make it an appealing ingredient in products designed for mental performance, alertness, and active lifestyles.
Read the full article from SupplySide Supplement Journal here.
References:
- Yoo C, Xing D, Gonzalez D, et al. Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients. 2021;13(11):3980. Published 2021 Nov 9. doi:10.3390/nu13113980. https://pmc.ncbi.nlm.nih.gov/articles/PMC8622427/