enfinity® (Paraxanthine) Powers Gains in Bulk’s New NO MATTER WHAT™ Pre-Workout

Sep 11, 2025

When it comes to pre-workout supplements, most formulas depend on caffeine to deliver energy. But not all athletes respond to caffeine the same way. Some experience jitters, others crash, and many struggle with sleep after late-afternoon workouts. 

That’s why Gains in Bulk created NO MATTER WHAT™ Pre-Workout, powered by enfinity® (paraxanthine). This new formula has already been highlighted by PricePlow, and it’s redefining how athletes fuel their training. 

 

Why enfinity® (Paraxanthine) is Different 

Caffeine is the world’s most common performance booster but nearly 50% of people are slow caffeine metabolizers1. For these athletes, caffeine often means less focus, more side effects, and restless nights. 

Pre-workout formulas using enfinity® (paraxanthine) solve this problem. Paraxanthine is the primary metabolite of caffeine, offering the benefits without the drawbacks: 

  • Delivers consistent energy and focus2 
  • Shorter half-life, helping to reduce sleep disruption compared to caffeine3 
  • Shown to improve post-exercise reaction times by 23% and reduce cognitive errors more effectively than caffeine4 
  • Supports metabolism and appetite control5 

With enfinity®, energy feels cleaner, more predictable, and better suited for modern athletes. 

 

Inside NO MATTER WHAT™ Pre-Workout 

NO MATTER WHAT™ is built on clinically researched ingredients that cover energy, endurance, and focus. The formula includes: 

  • enfinity® (paraxanthine) (300 mg) – Clean, consistent energy and cognitive benefits without the drawbacks of traditional caffeine 
  • L-Citrulline (6 g) – Boosts nitric oxide for pumps, blood flow, and stamina 
  • Beta-Alanine (3.2 g) – Supports muscles indirectly as the rate-limiting precursor to carnosine synthesis8 
  • Alpha-GPC (300 mg) – Supports focus, learning, and the mind-muscle connection9 
  • L-Theanine (250 mg) – Promotes calm focus, balancing stimulants6 
  • Pink Himalayan Salt (200 mg) – Provides electrolytes for hydration and performance8 

Every dose is transparent, fully disclosed, and clinically backed—no hidden blends, no guesswork. 

 

A Smarter Future for Pre-Workouts 

By choosing enfinity® (paraxanthine), Gains in Bulk is setting a new standard for pre-workout innovation. Instead of relying solely on caffeine, this formula uses paraxanthine to deliver energy that feels cleaner, steadier, and more reliable. 

For athletes who want a pre-workout without the caffeine crash, NO MATTER WHAT™ delivers, living up to its name and working no matter what. 

 

Learn More 

Read PricePlow’s full coverage of NO MATTER WHAT™ here.
Explore the science behind enfinity® (paraxanthine) and see how it’s changing the way supplements deliver energy. 

 

References 

  1. Lelo, A., et al. “Comparative Pharmacokinetics of Caffeine and Its Primary Demethylated Metabolites Paraxanthine, Theobromine and Theophylline in Man.” British Journal of Clinical Pharmacology, vol. 22, no. 2, Aug. 1986, pp. 177–182, doi:10.1111/j.1365-2125.1986.tb05246.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401099/ 
  2. Purpura, M., Jäger, R., & Falk, M. (2021). An assessment of mutagenicity, genotoxicity, acute-, subacute and subchronic oral toxicity of paraxanthine (1,7-dimethylxanthine). Food and Chemical Toxicology, 158, 112579. https://doi.org/10.1016/j.fct.2021.112579 
  3. ‌Lelo A, Birkett DJ, Robson RA, Miners JO. Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man. Br J Clin Pharmacol. 1986;22(2):177-182. doi:10.1111/j.1365-2125.1986.tb05246.x https://pubmed.ncbi.nlm.nih.gov/3756065/  
  4. Yoo, Choongsung, et al. “Paraxanthine Provides Greater Improvement in Cognitive Function than Caffeine after Performing a 10-Km Run.” Journal of the International Society of Sports Nutrition, vol. 21, no. 1, 9 May 2024, doi:10.1080/15502783.2024.2352779. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11089923/  
  5. Gross, Kristen N, et al. “A Dose-Response Study to Examine Paraxanthine’s Impact on Energy Expenditure, Hunger, Appetite, and Lipolysis.” Journal of Dietary Supplements, vol. 21, no. 5, 14 May 2024, pp. 608–632, doi:10.1080/19390211.2024.2351222. https://www.tandfonline.com/doi/full/10.1080/19390211.2024.2351222  
  6. Haskell, Crystal F., et al. “The Effects of L-Theanine, Caffeine and Their Combination on Cognition and Mood.” Biological Psychology, vol. 77, no. 2, Feb. 2008, pp. 113–122, doi:10.1016/j.biopsycho.2007.09.008. https://pubmed.ncbi.nlm.nih.gov/18006208/ 
  7. Kiesel, Kyle, et al. “Can Serious Injury in Professional Football Be Predicted by a Preseason Functional Movement Screen?” North American Journal of Sports Physical Therapy : NAJSPT, vol. 2, no. 3, Aug. 2007, pp. 147–58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953296/  
  8. Trexler, Eric T., et al. “International Society of Sports Nutrition Position Stand: Beta-Alanine.” Journal of the International Society of Sports Nutrition, vol. 12, no. 1, 15 July 2015, doi:10.1186/s12970-015-0090-y. https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/  
  9. Marcus, Lena, et al. “Evaluation of the Effects of Two Doses of Alpha Glycerylphosphorylcholine on Physical and Psychomotor Performance.” Journal of the International Society of Sports Nutrition, vol. 14, no. 1, 5 Oct. 2017, doi:10.1186/s12970-017-0196-5. https://pmc.ncbi.nlm.nih.gov/articles/PMC5629791/