Paraxanthine is a caffeine metabolite and has gained attention as a potential nootropic or mental performance enhancer. The study used a double-blind, placebo-controlled, crossover design, meaning participants took both a placebo and paraxanthine (enfinity®) on separate occasions without knowing which one they were taking.

The 13 healthy participants completed a series of cognitive tests before and after ingestion to measure the effects over 6 hours.

• Participants: 13 healthy male and female adults.
• Design: Randomized, double-blind, placebo-controlled, crossover study.
• Dosage: 200 mg of paraxanthine (enfinity®).

Key results:

• • Significant improvements in cognitive tasks like short-term memory and sustained attention.
  • Fewer errors in reasoning tasks (Wisconsin Card Sorting Test) after 6 hours.
  • Improved response times in memory retrieval tests (Sternberg Task) after 2 hours.
  • Sustained attention and vigilance were enhanced after 2 and 4 hours of ingestion.

The results indicate that paraxanthine (enfinity®) can help improve performance in tasks requiring memory and attention, with effects lasting up to 6 hours. This suggests that enfinity® may be a promising alternative to caffeine for those looking for improved cognitive performance without the side effects commonly associated with caffeine.

The researchers used a double-blind, placebo-controlled design with 12 healthy participants to compare the effects of different doses of paraxanthine (50 mg, 100 mg, and 200 mg) against a placebo. Participants were tested after both acute ingestion (one dose) and short-term use (7 days), focusing on cognitive tasks and side effects.

• Participants: 12 healthy adults, average age 22.7 years.
• Design: Randomized, double-blind, placebo-controlled, crossover study.
• Dosage: 50 mg, 100 mg, or 200 mg of paraxanthine (enfinity®).

Key results:

• • Cognitive benefits were seen at all doses, but the 100 mg and 200 mg doses had the most consistent improvements.
  • Participants taking 100 mg or 200 mg of paraxanthine (enfinity®) showed faster reaction times and improved accuracy on memory and executive function tests.
  • No significant side effects or changes in clinical chemistry were observed, indicating that paraxanthine (enfinity®) is safe at the doses tested.

This study provides valuable insights into how paraxanthine can enhance cognitive performance at different dosages. While all doses showed some cognitive benefits, the 100 mg and 200 mg doses were most effective, making enfinity® a powerful supplement for boosting mental clarity and focus.

The study followed international guidelines and used a series of toxicological tests to evaluate the safety profile of enfinity® (paraxanthine, >99% purity) in animal models.

• Participants: Laboratory rats (both male and female).
• Design: Series of mutagenicity, genotoxicity, and acute and repeated-dose oral toxicity studies.
• Dosage: Paraxanthine (enfinity®) was administered in doses of 75, 150, or 300 mg/kg of body weight per day.

Key results:

• • No evidence of mutagenicity or genotoxicity was found in various tests.
  • No mortality or toxic effects were observed in acute or subacute studies.
  • In the 90-day subchronic oral toxicity study, no adverse effects were seen even at the highest dose tested (300 mg/kg/day).
  • The No Observed Adverse Effect Level (NOAEL) was ≥ 300 mg/kg/day for both male and female rats.

This study provides compelling evidence that paraxanthine is safe for consumption at levels significantly higher than those typically used in supplements. With no observed adverse effects in both short- and long-term studies, enfinity® proves to be a safe and reliable choice for consumers looking to benefit from its cognitive-enhancing and energy-boosting properties.

Paraxanthine is the main metabolite of caffeine and has been shown to have stronger effects on physical performance with fewer side effects compared to caffeine. The researchers compared paraxanthine (enfinity®) to other popular performance-enhancing supplements, including L-theanine, alpha-GPC, and taurine, in a group of mice.

• Participants: Male Swiss Albino mice (5 groups of 8 mice each).
• Design: 4-week oral supplementation of paraxanthine or other ingredients with exercise performance evaluation.
• Dosage: Human equivalent dose (HED) of 100 mg paraxanthine daily.

Key results:

• • Paraxanthine significantly increased forelimb grip strength by 17% and treadmill endurance by 39%.
  • Muscle mass in the gastrocnemius and soleus muscles increased by 14% and 41%, respectively.
  • Paraxanthine doubled nitric oxide levels, while reducing triglycerides, LDL cholesterol, and total cholesterol, and raising HDL cholesterol compared to the control group.
  • Compared to L-theanine, alpha-GPC, and taurine, paraxanthine showed superior improvements in muscle strength, endurance, and cardiovascular health markers.

This study suggests that paraxanthine (enfinity®) supplementation could be a powerful option for athletes and individuals looking to improve muscle strength, endurance, and overall cardiovascular health. The benefits observed in mice are promising and may translate to human performance, making enfinity® a top choice for sports performance enhancement.

Using a double-blind, placebo-controlled, crossover design, researchers compared the effects of placebo versus 100 mg, 200 mg, and 300 mg doses of paraxanthine on various metabolic markers and perceptual responses.

• Participants: 21 healthy adults (13 males, 8 females), average age 26.
• Design: Randomized, double-blind, placebo-controlled, crossover study.
• Dosage: 100 mg, 200 mg, and 300 mg of enfinity®.

Key results:

• • Energy Expenditure: The 200 mg dose significantly increased energy expenditure compared to the placebo.
  • Hunger & Appetite: The 200 mg dose reduced hunger ratings at 30, 60, 90, and 180 minutes after ingestion compared to placebo.
  • Fat Oxidation: A trend towards increased fat oxidation was observed with the 200 mg dose at 90 and 120 minutes.
  • Free Fatty Acids: The 300 mg dose significantly increased free fatty acid levels compared to placebo.
  • Hemodynamics: No significant changes in blood pressure were noted, and heart rate slightly decreased with the 100 mg dose compared to placebo.

This study shows that paraxanthine (enfinity®) can help increase energy expenditure and reduce hunger, especially at a 200 mg dose. It also has potential benefits for fat metabolism, making it a promising ingredient for energy and weight management supplements.

Athletes often experience cognitive fatigue toward the end of intense exercise, impacting decision-making and performance. Caffeine is commonly used to counteract this, but habituation and genetic sensitivity can reduce its effectiveness. This study aimed to see if paraxanthine, a metabolite of caffeine, offers superior benefits without the same limitations.

• Participants: Healthy athletes who regularly engage in intense physical activity.
• Design: Randomized, double-blind, crossover study.
• Dosage: Paraxanthine (enfinity®) vs. caffeine, administered before or after a 10-km run.

Key results:

• • Paraxanthine improved post-exercise cognitive function more than caffeine.
  • Participants reported better focus and faster reaction times after taking paraxanthine compared to caffeine.
  • No evidence of tolerance issues or reduced efficacy from habitual caffeine use.
  • Paraxanthine provided consistent cognitive benefits even after intense physical exertion, where decision-making and reaction time are critical for athletic success.

This study suggests that paraxanthine (enfinity®) may be a superior alternative to caffeine for maintaining mental clarity and focus after intense exercise, offering athletes an edge in performance without the downsides of caffeine habituation or sensitivity.